Qualifications Bachelor of Medicine and Bachelor of Surgery (MBChB)
Fellow of the Royal Australasian College of Surgeons
GESA accredited for Endoscopy and Colonoscopy
Australian and New Zealand Hepatic, Pancreatic and Biliary Association
Doctorate in Clinical Surgery (DCLin Surg)
2011 – 2015 Doctorate of Clinical Surgery (University of Sydney)
2014 – 2015 AGITG, NHMRC Clinical Trials Fellow, Sydney
2012 – 2014 ANZHPBA fellowship (South Australia)
2008 – 2012 Fellowship in General Surgery (FRACS)
2000-2003 Bachelor of Medicine and Bachelor of Surgery (MBChB)
University of Auckland, New Zealand
1998-2000 Advanced Diploma in Health Sciences
International Medical University, Kuala Lumpur, Malaysia
General Surgeon, Prince Charles Hospital 2015
Locum VMO General Surgeon 2015
Upper GI fellow, Bankstown Hospital 2014 - 2015
Australasian GI Trials Group (AGITG) Fellow, NHMRC Clinical Trials Centre, Sydney 2014 - 2015
Hepatopancreatobiliary (ANZHPBA) Surgical Fellow
Flinders Medical Centre, Adelaide 2013
Royal Adelaide Hospital, Adelaide 2012
Advanced Surgical Trainee (SET) NSW 2008 – 2011
Nepean Hospital - Alma mater, Coffs Harbour Hospital, Mt Druitt Hospital, Westmead Hospital, Hawkesbury Hospital, Blacktown Hospital, Calvary Hospital, ACT
Basic Surgical Trainee (BST 1-2) 2006 -2007
Bankstown Hospital – Alma mater, Fairfield Hospital, Concord Hospital, Royal Prince Alfred Hospital.
RMO 1 at Nepean Hospital, Sydney 2005
Intern at Concord Hospital, Sydney 2004
Courses and Education
Developing a Career in Academic Surgery (DCAS) 2012
International HPB Meeting and courses, Paris 2012
ASC Kuala Lumpur Masterclasses in HPB Surgery 2012
Laparoscopic Liver Workshop Brisbane 2012
ASC Auckland Masterclasses in HPB Surgery 2013
Intraoperative liver ultrasound Diploma Serbia, Belgrade Professor Torzilli from Milan 2013
Introductory Biostatistics (University of Sydney) 2013
Quality and Health Improvement (ANZHPBA) 2013
Epidemiology Methods and Uses (University of Sydney) 2014
Quality and Safety in Healthcare (University of Sydney) 2014
Gastric surgery masterclass (Singapore ASC) 2014
Non Technical skills for Surgeons (NOTTS) 2014
Research Degree Supervision (University of Sydney) 2014
Infection prevention in healthcare (University of Sydney) 2014
Statistical Principles in Clinical Trials (University of Sydney) 2014
Asia Pacific Oncology Development Workshop (ACORD) 2014
Laparoscopic/ Robotic Liver workshop 2015
Transcystic bile duct exploration workshop 2015
Leadership, commitment to education, teaching, academic work
ANZHPBA Graduate Board Member 2014 - 2015
Reviewer for the HPB section of the ANZJS 2011 – Current
Reviewer for World Journal of Gastroenterology, World Journal Gastrointestinal Oncology, Case Reports in Surgery, World Journal of Surgical Oncology 2014- Current
Doctorate of Clinical Surgery, University of Sydney 2010 - 20145
Conjoint Associate Lecturer - University of Western Sydney
Mt Druitt / Blacktown Hospital Campus 2010 – 2012
Conjoint Lecturer – University of Western Sydney 2014 - Current
Campbelltown/ Bankstown Hospital
Organiser of the NSW ANZHPBA Journal Club meetings 2014
Lecturer, University of Adelaide 2015 – 2017
Grants, scholarship, awards
Nepean Medical Research grant 2010
Endoscopic stenting for malignant gastric outlet obstruction
ANZHPBA Covidien Travelling Scholarship Recipient 2013
Liver Ultrasound Course by Professor Torzilli, E-AHPBA in Serbia.
Best research paper HPB section, RACS ASC conference in Auckland 2013
“Padbury Trophy” winner for top exam result ANZHPBA 2013
Fellowship for trial protocol development Asia -Pacific
Clinical Oncology Research Development: (ACORD) Workshop 2014
Wrote the surgical substudies for the NHMRC grant application 2015
ACTICCA-1 trial: 2015
An international, multicenter adjuvant trial in resectable cholangiocarcinoma.
Jayaram G, Dashini M. Evaluation of fine needle aspiration cytology of salivary glands: an analysis of 141 cases. Malaysian J Pathology 2001; 23: 93-100.
Chandrasegaram MD, Plank LD, Windsor JA. The impact of total parenteral nutrition on the body composition of patients with acute pancreatitis. J Parenter Enteral Nutr (JPEN) 2005; 29: 65-73
Chandrasegaram MD, Celermajer DS, Wilson MK. Apical ballooning syndrome complicated by acute severe mitral regurgitation with left ventricular outflow obstruction. Journal of Cardiothoracic Surgery 2007; 2:14
Chandrasegaram MD, Harvey J. Full thickness versus split skin grafting in paediatric hand burns: A 10-year study of 174 patients. Journal of Burn Care and Research 2009; 30: 867-871
Chandrasegaram MD, Eslick G, Mansfield C, Liem H, Richardson M, Ahmed S, Cox MR.
Endoscopic stenting versus operative gastrojejunostomy in malignant gastric outlet obstruction – an institutional experience. Surgical Endoscopy 2012; 26: 323-9
Chandrasegaram MD, Rothwell LA, An EI, Miller RJ. Pathologies of the appendix: a 10-year review of 4670 appendicectomy specimens. Aust NZ J Surg 2012: 82: 844-847
Warren LR, Chandrasegaram MD, Madigan D, Neo EL, Worthley CS. Falciform ligament abscess from left sided portal pyaemia following malignant obstructive cholangitis. World J Surg Oncol 2012; 10: 278
Chandrasegaram MD, Chiam SC, Nguyen NQ, Ruszkiewicz A, Chung A, Neo EL, Chen JW, Worthley CS, Brooke-Smith ME. A case of pancreatic cancer in the setting of autoimmune pancreatitis with non-diagnostic serum markers. Case Rep Surg. 2013; 2013: 809023
Chandrasegaram MD, Chen DY, Tan CP, Neo EL, Dolan PM, Chen JW, Brooke-Smith ME, Cheetham G, Ruszkiewicz A, Worthley CS. Kras mutation is a local tumour event and not a field change in pancreato-biliary tumours. British J of Medicine and Medical Research 2013; 3: 2069-2075
Chandrasegaram MD, Chen DY, Tan CP, Neo EL, Dolan PM, Chen JW, Brooke-Smith ME, Cheetham G, Ruszkiewicz A, Worthley CS. KRAS mutation and DPC4 inactivation in endothelial Pancreato-biliary tumours. AHMRC Congress Nov 2012 (Abstract 415)
Warren LR, Chandrasegaram MD, Neo EL, Dolan PM, Tan CP, Chen JW, Worthley CS.
Large gas containing hepatic abscess following transarterial chemoembolisation. Aust NZ J Surg 2014; 84: 587-588
Nathan AD, Chandrasegaram MD, Dolan PM, Tan CP, Chen JW, Worthley CS, Neo EL. Palliative bypass for small bowel carcinoid with mesenteric mass and vascular encasement. Aust NZ J Surg 2014; 84:793-794
Chandrasegaram MD, Eslick GD, Lee W, Brooke-Smith ME, Padbury R, Worthley CS, Chen JW, Windsor JA. Anticoagulation policy following venous resection with pancreatectomy: a systematic review. HPB 2014; 16:691-698
Chandrasegaram MD, Shah A, Chen JW, Ruszkiewicz A, Astill D, Raju RS, Neo EL, Dolan P, Brooke-Smith M, Padbury R, Worthley CS. Oestrogen hormone receptors in Focal Nodular Hyperplasia. E-AHPBA (Published in abstract form)
HPB 2015; 17: 502-7
Barbour A, O’Rourke N, Samra JS, Haghighi KS, Kench J, Mitchell J, Pavlakis N, Burge ME, Fawcett J, Gananadha S, Harris M, Aghmesheh M, Chua YJ, Joubert WL, Chan MMK, Chandrasegaram MD, Yip S, Simes J, Gebski V, Goldstein D. A multicenter, phase II trial of preoperative gemcitabine and nab-paclitaxel for resectable pancreas cancer: The AGITG GAP study. J Clin Oncol 2015; 33: Suppl 3; Abstr 387
Chiam SC, Chandrasegaram MD, Chen JW, Khalid A, Mittinty MN, Neo EL, Tan CP, Dolan PM, Brooke-Smith M, Kanhere H, Worthley CS. Distribution and pathological features of pancreatic, ampullary, biliary and duodenal cancers resected with pancreaticoduodenectomy. World J Surgical Oncology 2015; 13:498
Chandrasegaram MD, Chen JW, Zalcberg J, Sjoquist K, Price T. Advances in molecular pathology and oncology of periampullary cancers. Pancreas 2015: accepted for publication
Raashed S, Chandrasegaram MD, Alsaleh K, Schlaphoff, Merrett ND. Vascular coil erosion into hepaticojejunostomy following hepatic arterial embolisation. BMC Surgery 2015; 15: 51
Ahn J, Raashed S, Chandrasegaram MD, Alsaleh K, Woodham BL, Teo A, Das A, Merrett ND, Apostolou C. Large retroperitoneal isolated fibrous cyst in absence of preceding trauma or acute pancreatitis. BMC Surgery 2015; 15:16
Chandrasegaram MD, Goldstein D, Simes J, Gebski V, Kench J, Gill A, Samra J, Nerrett ND, Richardson A, Fawcett J, Grimison P, Christophi C, Padbury R, Spry N, Haghighi K, Chen J, Nikfarjam M, O’Rourke N, Barbour A. Systematic review and meta-analysis of R0 rates in pancreatic cancer. Br J Surg 2015: accepted for publication
Chandrasegaram MD, Neo EL, Nathan AD, Dolan PM, Tan CP, Chen JW, Worthley CS.
Re: Palliative Bypass rarely resolves symptoms for unresectable mesenteric nodal neuroendocrine metastases. Aust NZ J Surg 2015: 85:197-8
Barbour A, O’Rourke N, Chandrasegaram MD, Chua YJ, Kench J, Samra JS, Pavlakis N, Haghighi KS, Yip S, Fawcett J, Donoghoe M, Walker K, Burge ME, Gananadha S, Harris M, Aghmesheh M, Joubert WL, Gebski V, Simes J, Goldstein D. A multicenter, phase II trial of preoperative gemcitabine and nab-paclitaxel for resectable pancreas cancer: The AGITG GAP study. J Clin Oncol 2015; 33: suppl; abstr 4115
Chandrasegaram M, Miller R.
A 10-year review of 4670 appendicectomies in Canberra – an analysis of negative appendicectomy rates, and pathologies of the appendix.
Presented at the ACT Surgical Registrar’s Paper Day, Canberra 2008
Chandrasegaram MD, Liang M, Sharma V, Zelas, P.
Venous Thromboembolism Prophylaxis – introducing a label to improve adherence
Poster Presentation at the Annual Continuing Education Meeting (ACE) Sydney 2008
Research and Other Presentations
Chandrasegaram MD, Harvey J.
Full thickness versus split skin grafting in paediatric hand burns: A 10-year study of 174 patients.
Presented at Annual Scientific Congress, Hong Kong 2008
Chandrasegaram MD, Eslick G, Kirby A, Mansfield C, Liem H, Richardson M, Ahmed S, Cox MR.
Endoscopic stenting versus operative gastrojejunostomy in malignant gastric outlet obstruction – an institutional experience
Presented at the Annual Scientific Congress, Perth, 2010
Chandrasegaram MD. “How to make a good quality surgical video”.
Presented at the ANZHPBA trainee day 2012, Brisbane
Best Runner up presentation
Chandrasegaram MD, Chen DY, Tan CP, Neo EL, Dolan PM, Chen JW, Brooke-Smith ME, Cheetham G, Ruszkiewicz A, Worthley CS.
KRAS mutation and DPC4 inactivation in endothelial Pancreato-biliary tumours.
Presented at the ANZHPBA meeting in Coolum, 2012 and the Australasian Pancreatic Club at the AHMRC Congress Nov 2012 (Poster - Abstract number 415), South Australian Gut Club 2013
Warren LR, Chandrasegaram MD, Madigan D, Neo EL, Worthley CS.
Falciform ligament abscess from left sided portal pyaemia following malignant obstructive cholangitis.
Presented at the Australasian Pancreatic Club at the AHMRC Congress Nov 2012 (Poster - Abstract number 420)
Nathan AD, Chandrasegaram MD, Neo EL, Dolan PM, Worthley CS.
Palliative bypass for small bowel carcinoid with mesenteric mass and vascular encasement – a case study
Presented at the Australasian Endocrine Society at the AHMRC Congress Nov 2012 (Poster - Abstract number 436)
Manju Chandrasegaram, Guy Eslick, Wayne Lee, Rob Padbury, Christopher Worthley, John Chen.
Meta-analysis of anticoagulation regimens and outcomes following portal vein resection during pancreatic resection
Presented at the RACS Annual Scientific Congress, Auckland 2013
Presented at the RACS South Australia, Northern Territory and Western Australia Annual Scientific Meeting, Barossa Valley 2013
Manju Chandrasegaram, Ali Shah, Ravish Raju, Andrew Ruszkiewicz, David Astill, Eu Ling Neo, Paul Dolan, Chuan Ping Tan, Mark Brooke-Smith, John Chen, Rob Padbury, Worthley CS. Oestrogen receptor expression in focal nodular hyperplasia – evidence of a hormonal disease. Presented at the E-AHPBA, Serbia, Belgrade 2013
Research and Other Presentations (cont.)
Barbour A, O’Rourke N, Samra JS, Haghighi KS, Kench J, Mitchell J, Pavlakis N, Burge ME, Fawcett J, Gananadha S, Harris M, Aghmesheh M, Chua YJ, Joubert WL, Chan MMK, Chandrasegaram MD, Yip S, Simes J, Gebski V, Goldstein D.
A multicenter, phase II trial of preoperative gemcitabine and nab-paclitaxel for resectable pancreas cancer: The AGITG GAP study.
ASCO Gastrointestinal cancers Symposium 2015: Accepted for poster presentation
Rob Padbury, Manju Chandrasegaram. Bile duct Injuries – early versus late repair. (Conference Symposium on Bile Duct Injuries). Presented at the E-AHPBA, Serbia, Belgrade 2013 and ANZHPBA Queenstown, New Zealand 2014
Manju Chandrasegaram. Hepatocellular Carcinoma – When to resect and when to transplant
Presented at the ANZHPBA/ ANZGOSA Trainee Day, Melbourne 2013 (Best Runner up)
Manju Chandrasegaram, John Chen, Worthley CS. Concept Clinical Trial in Pancreatic Cancer (Anti-EGFR treatment in Wild-type KRAS pancreatic cancer)
Presented at the Australian Pancreatic Club, AGITG Research Symposium 2013
Manju Chandrasegaram. Seminal research paper presentation from Mayo Clinic “Liver Transplantation with Neoadjuvant Chemoradiation is more effective than resection for Hilar Cholangiocarcinoma”.
Presented at the Clinical Oncological Society of Australia (COSA) Trainee Day, Adelaide 2013
Chandrasegaram MD, Merrett, N. Introduction to Surgical Jaundice
Presented at the University of Western Sydney Conference Week April 2014
Chandrasegaram MD. Understanding pancreatic cancer genomes and the AGITG IMPACT trial
Presented at the NSW ANZHPBA journal club meeting in July 2014
Chandrasegaram MD, Merrett N, Karapetis C, Chen J
Concept trial: Phase 2 randomised trial of neoadjuvant chemotherapy comparing Folfirinox versus Gemcitabine/ abraxane in Borderline resectable pancreatic cancer.
Presented at the Pancreas Cancer Workshop by Australian Pancreatic Club and Australian Gastrointestinal Trial Group (AGITG) in Brisbane August 2014
Chandrasegaram MD. Focal nodular hyperplasia, can we discharge after diagnosis or do we follow long term?
Presented at ANZHPBA and ANZGOSA annual conference in Queenstown, New Zealand October 2014
Chandrasegaram MD. Surgical and Pathological Outcomes in Pancreatic Cancer.
AGITG Pancreatic Cancer Surgical Standards Workshop, Sydney July 2015