Manju Chandrasegaram

Qualifications         Bachelor of Medicine and Bachelor of Surgery (MBChB)

    Fellow of the Royal Australasian College of Surgeons

(FRACS)

GESA accredited for Endoscopy and Colonoscopy

Australian and New Zealand Hepatic, Pancreatic and Biliary Association

(ANZHPBA) Graduate,

Doctorate in Clinical Surgery (DCLin Surg)

Academic History

2011 – 2015        Doctorate of Clinical Surgery (University of Sydney)

2014 – 2015        AGITG, NHMRC Clinical Trials Fellow, Sydney

2012 – 2014        ANZHPBA fellowship (South Australia)

2008 – 2012         Fellowship in General Surgery (FRACS)

2000-2003        Bachelor of Medicine and Bachelor of Surgery (MBChB)

University of Auckland, New Zealand

1998-2000        Advanced Diploma in Health Sciences

International Medical University, Kuala Lumpur, Malaysia

Employment History

  • General Surgeon, Prince Charles Hospital            2015

  • Locum VMO General Surgeon                2015

  • Upper GI fellow, Bankstown Hospital            2014 - 2015

  • Australasian GI Trials Group (AGITG) Fellow, NHMRC Clinical Trials Centre, Sydney        2014 - 2015

  • Hepatopancreatobiliary (ANZHPBA) Surgical Fellow                    

    Flinders Medical Centre, Adelaide            2013

    Royal Adelaide Hospital, Adelaide            2012

  • Advanced Surgical Trainee (SET) NSW            2008 – 2011

Nepean Hospital - Alma mater, Coffs Harbour Hospital, Mt Druitt Hospital, Westmead Hospital, Hawkesbury Hospital, Blacktown Hospital, Calvary Hospital, ACT

  • Basic Surgical Trainee (BST 1-2)                2006 -2007

Bankstown Hospital – Alma mater, Fairfield Hospital, Concord Hospital, Royal Prince Alfred Hospital.

  • RMO 1 at Nepean Hospital, Sydney                2005

  • Intern at Concord Hospital, Sydney                 2004

Courses and Education

  • Developing a Career in Academic Surgery (DCAS)            2012

  • International HPB Meeting and courses, Paris            2012

  • ASC Kuala Lumpur Masterclasses in HPB Surgery            2012

  • Laparoscopic Liver Workshop Brisbane                2012

  • ASC Auckland Masterclasses in HPB Surgery                2013

  • Intraoperative liver ultrasound Diploma Serbia, Belgrade Professor Torzilli from Milan                    2013

  • Introductory Biostatistics (University of Sydney)            2013

  • Quality and Health Improvement (ANZHPBA)            2013

  • Epidemiology Methods and Uses (University of Sydney)        2014

  • Quality and Safety in Healthcare (University of Sydney)        2014

  • Gastric surgery masterclass (Singapore ASC)                2014

  • Non Technical skills for Surgeons (NOTTS)                2014

  • Research Degree Supervision (University of Sydney)            2014

  • Infection prevention in healthcare  (University of Sydney)        2014

  • Statistical Principles in Clinical Trials (University of Sydney)        2014

  • Asia Pacific Oncology Development Workshop (ACORD)        2014

  • Laparoscopic/ Robotic Liver workshop                2015

  • Transcystic bile duct exploration workshop                2015

Leadership, commitment to education, teaching, academic work

  • ANZHPBA Graduate Board Member                    2014 - 2015

  • Reviewer for the HPB section of the ANZJS                 2011 – Current

  • Reviewer for World Journal of Gastroenterology, World Journal Gastrointestinal Oncology, Case Reports in Surgery, World Journal of Surgical Oncology                2014- Current

  • Doctorate of Clinical Surgery, University of Sydney            2010 - 20145

  • Conjoint Associate Lecturer - University of Western Sydney

    • Mt Druitt / Blacktown Hospital Campus            2010 – 2012

  • Conjoint Lecturer – University of Western Sydney            2014 - Current

    • Campbelltown/ Bankstown Hospital        

  • Organiser of the NSW ANZHPBA Journal Club meetings        2014

  • Lecturer, University of Adelaide                    2015 – 2017

Grants, scholarship, awards

  • Nepean Medical Research grant                     2010

    • Endoscopic stenting for malignant gastric outlet obstruction

  • ANZHPBA Covidien Travelling Scholarship Recipient             2013

    • Liver Ultrasound Course by Professor Torzilli,  E-AHPBA in Serbia.

  • Best research paper HPB section, RACS ASC conference in Auckland    2013

  • “Padbury Trophy” winner for top exam result ANZHPBA         2013

  • Fellowship for trial protocol development Asia -Pacific

Clinical Oncology Research Development:     (ACORD) Workshop     2014

  • Wrote the surgical substudies for the NHMRC grant application    2015

ACTICCA-1 trial: 2015

An international, multicenter adjuvant trial in resectable cholangiocarcinoma.    

Research Publications

  • Jayaram G, Dashini M. Evaluation of fine needle aspiration cytology of salivary glands: an analysis of 141 cases.  Malaysian J Pathology 2001; 23: 93-100.

  • Chandrasegaram MD, Plank LD, Windsor JA. The impact of total parenteral nutrition on the body composition of patients with acute pancreatitis. J Parenter Enteral Nutr (JPEN) 2005; 29: 65-73

  • Chandrasegaram MD, Celermajer DS, Wilson MK. Apical ballooning syndrome complicated by acute severe mitral regurgitation with left ventricular outflow obstruction. Journal of Cardiothoracic Surgery 2007; 2:14

  • Chandrasegaram MD, Harvey J.  Full thickness versus split skin grafting in paediatric hand burns: A 10-year study of 174 patients. Journal of Burn Care and Research 2009; 30: 867-871

  • Chandrasegaram MD, Eslick G, Mansfield C, Liem H, Richardson M, Ahmed S, Cox MR.

Endoscopic stenting versus operative gastrojejunostomy in malignant gastric outlet obstruction – an institutional experience.  Surgical Endoscopy 2012; 26: 323-9

  • Chandrasegaram MD, Rothwell LA, An EI, Miller RJ. Pathologies of the appendix: a 10-year review of 4670 appendicectomy specimens. Aust NZ J Surg 2012: 82: 844-847

  • Warren LR, Chandrasegaram MD, Madigan D, Neo EL, Worthley CS. Falciform ligament abscess from left sided portal pyaemia following malignant obstructive cholangitis. World J Surg Oncol 2012; 10: 278

  • Chandrasegaram MD, Chiam SC, Nguyen NQ, Ruszkiewicz A, Chung A, Neo EL, Chen JW, Worthley CS, Brooke-Smith ME. A case of pancreatic cancer in the setting of autoimmune pancreatitis with non-diagnostic serum markers. Case Rep Surg. 2013; 2013: 809023

  • Chandrasegaram MD, Chen DY, Tan CP, Neo EL, Dolan PM, Chen JW, Brooke-Smith ME, Cheetham G, Ruszkiewicz A, Worthley CS. Kras mutation is a local tumour event and not a field change in pancreato-biliary tumours. British J of Medicine and Medical Research 2013; 3: 2069-2075

  • Chandrasegaram MD, Chen DY, Tan CP, Neo EL, Dolan PM, Chen JW, Brooke-Smith ME, Cheetham G, Ruszkiewicz A, Worthley CS. KRAS mutation and DPC4 inactivation in endothelial Pancreato-biliary tumours. AHMRC Congress Nov 2012 (Abstract 415)

  • Warren LR, Chandrasegaram MD, Neo EL, Dolan PM, Tan CP, Chen JW, Worthley CS.

Large gas containing hepatic abscess following transarterial chemoembolisation. Aust NZ J Surg 2014; 84: 587-588

  • Nathan AD, Chandrasegaram MD, Dolan PM, Tan CP, Chen JW, Worthley CS, Neo EL. Palliative bypass for small bowel carcinoid with mesenteric mass and vascular encasement.  Aust NZ J Surg 2014; 84:793-794

  • Chandrasegaram MD, Eslick GD, Lee W, Brooke-Smith ME, Padbury R, Worthley CS, Chen JW, Windsor JA. Anticoagulation policy following venous resection with pancreatectomy: a systematic review. HPB 2014; 16:691-698

Research Publications

  • Chandrasegaram MD, Shah A, Chen JW, Ruszkiewicz A, Astill D, Raju RS, Neo EL, Dolan P, Brooke-Smith M, Padbury R, Worthley CS. Oestrogen hormone receptors in Focal Nodular Hyperplasia. E-AHPBA (Published in abstract form)

HPB 2015; 17: 502-7

  • Barbour A, O’Rourke N, Samra JS, Haghighi KS, Kench J, Mitchell J, Pavlakis N, Burge ME, Fawcett J, Gananadha S, Harris M, Aghmesheh M, Chua YJ, Joubert WL, Chan MMK, Chandrasegaram MD, Yip S, Simes J, Gebski V, Goldstein D. A multicenter, phase II trial of preoperative gemcitabine and nab-paclitaxel for resectable pancreas cancer: The AGITG GAP study. J Clin Oncol 2015; 33: Suppl 3; Abstr 387

  • Chiam SC, Chandrasegaram MD, Chen JW, Khalid A, Mittinty MN, Neo EL, Tan CP, Dolan PM, Brooke-Smith M, Kanhere H, Worthley CS. Distribution and pathological features of pancreatic, ampullary, biliary and duodenal cancers resected with pancreaticoduodenectomy. World J Surgical Oncology 2015; 13:498

  • Chandrasegaram MD, Chen JW, Zalcberg J, Sjoquist K, Price T. Advances in molecular pathology and oncology of periampullary cancers. Pancreas 2015: accepted for publication

  • Raashed S, Chandrasegaram MD, Alsaleh K, Schlaphoff, Merrett ND.  Vascular coil erosion into hepaticojejunostomy following hepatic arterial embolisation. BMC Surgery 2015; 15: 51

  • Ahn J, Raashed S, Chandrasegaram MD, Alsaleh K, Woodham BL, Teo A, Das A, Merrett ND, Apostolou C. Large retroperitoneal isolated fibrous cyst in absence of preceding trauma or acute pancreatitis. BMC Surgery 2015; 15:16

  • Chandrasegaram MD, Goldstein D, Simes J, Gebski V, Kench J, Gill A, Samra J, Nerrett ND, Richardson A, Fawcett J, Grimison P, Christophi C, Padbury R, Spry N, Haghighi K, Chen J, Nikfarjam M, O’Rourke N, Barbour A. Systematic review and meta-analysis of R0 rates in pancreatic cancer. Br J Surg 2015: accepted for publication

  • Chandrasegaram MD, Neo EL, Nathan AD, Dolan PM, Tan CP, Chen JW, Worthley CS.

Re: Palliative Bypass rarely resolves symptoms for unresectable mesenteric nodal neuroendocrine metastases.  Aust NZ J Surg 2015: 85:197-8

  • Barbour A, O’Rourke N, Chandrasegaram MD, Chua YJ, Kench J, Samra JS, Pavlakis N, Haghighi KS, Yip S, Fawcett J, Donoghoe M, Walker K, Burge ME, Gananadha S, Harris M, Aghmesheh M, Joubert WL, Gebski V, Simes J, Goldstein D. A multicenter, phase II trial of preoperative gemcitabine and nab-paclitaxel for resectable pancreas cancer: The AGITG GAP study. J Clin Oncol 2015; 33: suppl; abstr 4115

  • Chandrasegaram M, Miller R.

A 10-year review of 4670 appendicectomies in Canberra – an analysis of negative appendicectomy rates, and pathologies of the appendix.

Presented at the ACT Surgical Registrar’s Paper Day, Canberra 2008

  • Chandrasegaram MD, Liang M, Sharma V, Zelas, P.

Venous Thromboembolism Prophylaxis – introducing a label to improve adherence

Poster Presentation at the Annual Continuing Education Meeting (ACE) Sydney 2008

Research and Other Presentations

  • Chandrasegaram MD, Harvey J.

Full thickness versus split skin grafting in paediatric hand burns: A 10-year study of 174 patients.

Presented at Annual Scientific Congress, Hong Kong 2008

  • Chandrasegaram MD, Eslick G, Kirby A, Mansfield C, Liem H, Richardson M, Ahmed S, Cox MR.

Endoscopic stenting versus operative gastrojejunostomy in malignant gastric outlet obstruction – an institutional experience

Presented at the Annual Scientific Congress, Perth, 2010

  • Chandrasegaram MD. “How to make a good quality surgical video”.

Presented at the ANZHPBA trainee day 2012, Brisbane

Best Runner up presentation

  • Chandrasegaram MD, Chen DY, Tan CP, Neo EL, Dolan PM, Chen JW, Brooke-Smith ME, Cheetham G, Ruszkiewicz A, Worthley CS.

KRAS mutation and DPC4 inactivation in endothelial Pancreato-biliary tumours.

Presented at the ANZHPBA meeting in Coolum, 2012 and the Australasian Pancreatic Club at the AHMRC Congress Nov 2012 (Poster - Abstract number 415), South Australian Gut Club 2013

  • Warren LR, Chandrasegaram MD, Madigan D, Neo EL, Worthley CS.

Falciform ligament abscess from left sided portal pyaemia following malignant obstructive cholangitis.

Presented at the Australasian Pancreatic Club at the AHMRC Congress Nov 2012 (Poster - Abstract number 420)

  • Nathan AD, Chandrasegaram MD, Neo EL, Dolan PM, Worthley CS.

Palliative bypass for small bowel carcinoid with mesenteric mass and vascular encasement – a case study

Presented at the Australasian Endocrine Society at the AHMRC Congress Nov 2012 (Poster - Abstract number 436)

  • Manju Chandrasegaram, Guy Eslick, Wayne Lee, Rob Padbury, Christopher Worthley, John Chen.

Meta-analysis of anticoagulation regimens and outcomes following portal vein resection during pancreatic resection

Presented at the RACS Annual Scientific Congress, Auckland     2013

Presented at the RACS South Australia, Northern Territory and Western Australia Annual Scientific Meeting, Barossa Valley    2013

  • Manju Chandrasegaram, Ali Shah, Ravish Raju, Andrew Ruszkiewicz, David Astill, Eu Ling Neo, Paul Dolan, Chuan Ping Tan, Mark Brooke-Smith, John Chen, Rob Padbury, Worthley CS. Oestrogen receptor expression in focal nodular hyperplasia – evidence of a hormonal disease. Presented at the E-AHPBA, Serbia, Belgrade 2013

Research and Other Presentations (cont.)

  • Barbour A, O’Rourke N, Samra JS, Haghighi KS, Kench J, Mitchell J, Pavlakis N, Burge ME, Fawcett J, Gananadha S, Harris M, Aghmesheh M, Chua YJ, Joubert WL, Chan MMK, Chandrasegaram MD, Yip S, Simes J, Gebski V, Goldstein D.

A multicenter, phase II trial of preoperative gemcitabine and nab-paclitaxel for resectable pancreas cancer: The AGITG GAP study.

ASCO Gastrointestinal cancers Symposium 2015: Accepted for poster presentation

  • Rob Padbury, Manju Chandrasegaram. Bile duct Injuries – early versus late repair. (Conference Symposium on Bile Duct Injuries). Presented at the E-AHPBA, Serbia, Belgrade 2013 and ANZHPBA Queenstown, New Zealand 2014

  • Manju Chandrasegaram. Hepatocellular Carcinoma – When to resect and when to transplant

Presented at the ANZHPBA/ ANZGOSA Trainee Day, Melbourne 2013 (Best Runner up)

  • Manju Chandrasegaram, John Chen, Worthley CS. Concept Clinical Trial in Pancreatic Cancer (Anti-EGFR treatment in Wild-type KRAS pancreatic cancer)

Presented at the Australian Pancreatic Club, AGITG Research Symposium 2013

  • Manju Chandrasegaram. Seminal research paper presentation from Mayo Clinic “Liver Transplantation with Neoadjuvant Chemoradiation is more effective than resection for Hilar Cholangiocarcinoma”.

Presented at the Clinical Oncological Society of Australia (COSA) Trainee Day, Adelaide 2013

  • Chandrasegaram MD, Merrett, N. Introduction to Surgical Jaundice

Presented at the University of Western Sydney Conference Week April 2014

  • Chandrasegaram MD. Understanding pancreatic cancer genomes and the AGITG IMPACT trial

Presented at the NSW ANZHPBA journal club meeting in July 2014

  • Chandrasegaram MD, Merrett N, Karapetis C, Chen J

Concept trial: Phase 2 randomised trial of neoadjuvant chemotherapy comparing Folfirinox versus Gemcitabine/ abraxane in Borderline resectable pancreatic cancer.

Presented at the Pancreas Cancer Workshop by Australian Pancreatic Club and Australian Gastrointestinal Trial Group (AGITG) in Brisbane August 2014

  • Chandrasegaram MD. Focal nodular hyperplasia, can we discharge after diagnosis or do we follow long term?

Presented at ANZHPBA and ANZGOSA annual conference in Queenstown, New Zealand October 2014

  • Chandrasegaram MD. Surgical and Pathological Outcomes in Pancreatic Cancer.

AGITG Pancreatic Cancer Surgical Standards Workshop, Sydney July 2015